HA Dermal Filler, Hyaluronic Acid Filler, Cross-linked HA Filler
Hyaluronic Acid - HA
HA is the same in all species
· Species with HA have the same structure
· HA extracted from Bacteria is identified as same as natural HA
Hydrophilicity of HYALURONIC ACID
· Random coil form, HA is composed of di-saccharides
PNETTM Gel - Stabilization explained
The unique and patented stabilization technique ensures that the natural cross-linked and entangled HA network is kept in place by introducing a limited number of synthetic cross-links, i.e. minimal modification
PNET (Preserved Natural Entanglement Technology)technology
Cross linking process
· Ideal cross linking: 100% of BDDE participate in cross linking, No not-linked BDDE exists.
· Some BDDE partially participated in cross linked(Open cross linked), reported to causes adverse event
· USA FDA guide line: below 2 ppm of Open cross linked/non-cross linked BDDE
PNET (Preserved Natural Entanglement Technology)technology
· Increase crosslinking efficacy (Low BDDE) lead to minimize Open-cross linked BDDE
· Inactive open-cross linked BDDE through 1st cleaning process
· Eliminate free BDDE again in 2nd cleaning process
Desirable characteristics of an HA filler
· High lifting capacity to create volume and stay where injected
· High similarity to natural HA to preserve biocompatibility
· Controlled particle size to enable tissue tailor concept
Lifting capacity
Gel strength
Quantifiable property of gel that describes the ability to resist deformation
Determined in vitro by rheology
A strong gel will have a high overall resistance to deformation, G*
Lifting capacity
Effect of gel strength in the body i.e. capacity of the implant to resist deformation
· Estimated in vivo by the clinician – and consumer
Gel particles
HA gels do not flow
Stretch, bend, etc.. but not flow
Because of this, the implant can not be in one single piece of gel
Therefore all HA gel fillers are made up of HA gel particles!
PNETTM Gel - unique characteristics
· Minimal modification
· Outstanding lifting capacity
· Long duration
Company Overview
JOHA Meditech is a specialized supplier of Aesthetic Products, Pharmaceutical products and Medical Appliances. We also provide with Medical Tourism and Academy Program.
JOHA Meditech was founded in 2015 with the name of KMA (Korea Med & Academy) and changed to a corporation.
We are exporting certified aesthetic products, related devices, health foods, medical cosmetics and pharmaceutical products. Medical Tourism for foreign patients and Academy programs for doctors are another specialty of our business.
Our strength is to verify our manufacturers before we sell to our customers. We are focusing on finding high quality products first. Our customers will be satisfied with all the products we supply and fast service.
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